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QUANTITATIVE STUDY ON ANTI-PEST ACTIVITY OF NATURAL PRODUCTS BASED ON VISUALIZATION FRAMEWORK OF KNOWLEDGE

Frontiers of Agricultural Science and Engineering 2023, Volume 10, Issue 2,   Pages 306-332 doi: 10.15302/J-FASE-2023488

Abstract:

● Using visual analysis to predict the trend of natural product pest

Keywords： anti-pest activity     crop protection     insect pest     natural product     visual analysis    

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Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellular

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 467-482 doi: 10.1007/s11684-021-0869-y

Abstract: Cabozantinib, mainly targeting cMet and vascular endothelial growth factor receptor 2, is the second-line treatment for patients with advanced hepatocellular carcinoma (HCC). However, the lower response rate and resistance limit its enduring clinical benefit. In this study, we found that cMet-low HCC cells showed primary resistance to cMet inhibitors, and the combination of cabozantinib and mammalian target of rapamycin (mTOR) inhibitor, rapamycin, exhibited a synergistic inhibitory effect on the in vitro cell proliferation and in vivo tumor growth of these cells. Mechanically, the combination of rapamycin with cabozantinib resulted in the remarkable inhibition of AKT, extracellular signal-regulated protein kinases, mTOR, and common downstream signal molecules of receptor tyrosine kinases; decreased cyclin D1 expression; and induced cell cycle arrest. Meanwhile, rapamycin enhanced the inhibitory effects of cabozantinib on the migration and tubule formation of human umbilical vascular endothelial cells and human growth factor-induced invasion of cMet inhibitor-resistant HCC cells under hypoxia condition. These effects were further validated in xenograft models. In conclusion, our findings uncover a potential combination therapy of cabozantinib and rapamycin to combat cabozantinib-resistant HCC.

Keywords： hepatocellular carcinoma     cabozantinib     primary resistance     rapamycin    

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RESEARCH AND APPLICATION OF CROP PEST MONITORING AND EARLY WARNING TECHNOLOGY IN CHINA

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1,   Pages 19-36 doi: 10.15302/J-FASE-2021411

Abstract: ., fall armyworm), decreasing agricultural biodiversity, and other factors, a wide range of crop pestthe use of science and technology in monitoring and early warning of major crop pests provides better pestThis review summarizes the most fundamental information on pest monitoring and early warning in Chinaespecially of cross border pests such as fall armyworm and locust, by international cooperation across pest-related

Keywords： China / law / early warning system and national crop pest monitoring / pest management / regulation and    

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Design, synthesis and HIV-RT inhibitory activity of novel thiazolidin-4-one derivatives

Hua CHEN, Zaihong GUO, Qingmei YIN, Xiaoxu DUAN, Yunjing GU, Xiaoliu LI

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 2,   Pages 231-237 doi: 10.1007/s11705-010-1022-7

Abstract: C-5 on thiazolidin-4-one ring were designed, synthesized and evaluated for their HIV-RT inhibitory activityPreliminary anti-HIV-RT test of these derivatives indicated that compounds – , (propionyloxy groupat C-5) showed moderate HIV-RT inhibitory activity and compounds and with methyl at C-5 showed aweak HIV-RT inhibitory activity.to anti-HIV-RT activity and that the steric effect might play a critical role in the anti-HIV RT activity

Keywords： 5-subsituted thiazolidin-4-ones     Pummerer reaction     anti-HIV-RT activity     SARs    

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BIOINSECTICIDES AS FUTURE MAINSTREAM PEST CONTROL AGENTS: OPPORTUNITIES AND CHALLENGES

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1,   Pages 82-97 doi: 10.15302/J-FASE-2021404

Abstract:

Bioinsecticides are naturally-occurring substances from different sources that control insect pests. Ideal bioinsecticides should have low toxicity to non-target organisms. They should also be easily degraded in sewage treatment works and natural environments, highly effective in small quantities and affect target pests only. Public concerns about possible side-effects of synthetic pesticides have accelerated bioinsecticide research and development. However, to develop bioinsecticides into mainstream products, their high production costs, short shelf-life and often uncertain modes of action need to be considered. This review summarizes current progress on bioinsecticides which are categorized as biochemical insecticides and their derivatives, plant-incorporated protectants, and microbial bioinsecticides. The current constraints that prevent bioinsecticides from being widely used are discussed and future research directions are proposed.

 

Keywords： biochemical insecticide / bioinsecticide / microbial bioinsecticides / plant-incorporated protectant / RNA insecticide    

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Pest management with biopesticides

James N. SEIBER, Joel COATS, Stephen O. DUKE, Aaron D. GROSS

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 3,   Pages 295-300 doi: 10.15302/J-FASE-2018238

Abstract: but without many of the non-target effects, promising a better record of safety and sustainability in pest

Keywords： biopesticide     GMO crops     pest management    

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SUSTAINABLE PLANT PEST MANAGEMENT THROUGH OPTIMIZATION AND MINIMIZATION

Plant Production and Protection Division (NSP), Food and Agriculture Organization of the United Nations (FAO), Viale delle Terme di Caracalla, 00153 Rome, Italy

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1,   Pages 161-166 doi: 10.15302/J-FASE-2021426

Abstract: Overreliance on pesticides as the primary tool for plant pest management leads to problems such as pesticideresistance and pest resurgence.There is clearly a need for a shift in pest management strategies and practices globally.production agroecosystems through soil conservation practices and cropping diversification can improve pestinstruments should be wielded to provide an enabling environment for the transformation to sustainable plant pest
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Research on the business model innovation of wind power equipment manufacturing industry in China based on industrial chain

Hu Xuhua, ,,Shi Fangyan and Xu Junjie

Strategic Study of CAE 2015, Volume 17, Issue 3,   Pages 88-95

Abstract: And the strategic pattern of business model is discussed based on PEST analysis .The concept of business

Keywords： wind power equipment manufacturing industry； business model innovation； industrial chain；PEST analysis    

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Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 729-746 doi: 10.1007/s11684-022-0978-2

Abstract: The effect of anti-programmed cell death 1 (anti-PD-1) immunotherapy is limited in patients with hepatocellularThe response to anti-PD-1 treatment is associated with A. muciniphila abundance in many tumorsHere, anti-PD-1 treatment decreased A. muciniphila abundance in the colon, but increased YAP1Yap1 knockout enhanced anti-PD-1 efficacy.Our findings suggested that the combination anti-PD-1 with DHA is an effective strategy for liver tumor

Keywords： hepatocellular carcinoma     YAP1     Akkermansia muciniphila     anti-PD-1     dihydroartemisinin     bile acid    

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A modular cable-driven humanoid arm with anti-parallelogram mechanisms and Bowden cables

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 1, doi: 10.1007/s11465-022-0722-2

Abstract: This paper proposes a novel modular cable-driven humanoid arm with anti-parallelogram mechanisms (APMs

Keywords： modular robotic arm     anti-parallelogram mechanism     Bowden cable     humanoid arm     lightweight joint design    

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Operation Mode of General Aviation Companies and Related Enterprises in China

Song Weiwei, Zhao Lijie, Xiang Song, Wang Yue, Li Zuoxue

Strategic Study of CAE 2019, Volume 21, Issue 3,   Pages 127-132 doi: 10.15302/J-SSCAE-2019.03.021

Abstract: the internal advantages, disadvantages, opportunities, and external threats of the company by using a PEST-SWOT

Keywords： transportation     general aviation company     related enterprises     operation mode     SWOT-PEST analysis method    

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Anti-biofouling strategies for implantable biosensors of continuous glucose monitoring systems

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12,   Pages 1866-1878 doi: 10.1007/s11705-023-2340-x

Abstract: review, research efforts over the past few years to mitigate the immune responses by enhancing the anti-biofoulinglayers on the biosensor surface, such as drug-releasing membranes, hydrogels, hydrophilic membranes, anti-biofoulinginformation, which is likely to aid in the research and development of novel CGM systems with profound anti-biofouling

Keywords： implantable glucose biosensor     anti-biofouling     continuous glucose monitoring     immune responses    

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Lignin-derived dual-function red light carbon dots for hypochlorite detection and anti-counterfeiting

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 7,   Pages 966-975 doi: 10.1007/s11705-022-2244-1

Abstract: Compared with green and blue fluorescent materials, red SPN-CDs have desirable anti-interference properties

Keywords： alkali lignin     red light carbon dots     hypochlorite     encryption and anti-counterfeiting    

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Modulatory effect on dyslipidemia and anti-atherosclerotic function of in newly diagnosed type 2 diabetes

SUN Mingxiao, WANG Yao, CHI Jiamin

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 174-177 doi: 10.1007/s11684-008-0032-z

Abstract: The modulatory effect of on dyslipidemia and the preventive effect on atherosclerosis in newly diagnosed type 2 diabetic patients were studied. A prospective clinical trial was conducted to test the effectiveness of in selected 201 newly diagnosed type 2 diabetic patients. All patients were randomly divided into two groups: 108 with therapy and 93 without therapy. The mean follow-up period was 22 months. The blood glucose and blood pressure of all patients were under control. Serum levels of total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) were significantly lowered and their decreased percentages were significantly higher in therapy group ( < 0.05). The number of patients with arteria iliaca intima thickening was significantly lower in group of therapy ( = 0.024). With stepwise multivariate logistic regression analysis, the decreased percentage of TG was significantly and independently related with the decreased number of patients with arteria iliaca intima thickening ( = 0.005). The study demonstrates that therapy is effective on modulating dyslipidemia in newly diagnosed type 2 diabetes patients, and may be related with the improvement of early atherosclerosis.
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Preparation of reverse osmosis membrane with high permselectivity and anti-biofouling properties for

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 7, doi: 10.1007/s11783-021-1497-0

Abstract:

• Nanoparticle incorporation and anti-biofouling grafting were integrated

Keywords： Anti-biofouling grafting     Nanoparticle incorporation     Sterilization rates     Water flux     Water flux recovery    

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Title Author Date Type Operation

QUANTITATIVE STUDY ON ANTI-PEST ACTIVITY OF NATURAL PRODUCTS BASED ON VISUALIZATION FRAMEWORK OF KNOWLEDGE

Journal Article

Rapamycin enhances the anti-tumor activity of cabozantinib in cMet inhibitor-resistant hepatocellular

Journal Article

RESEARCH AND APPLICATION OF CROP PEST MONITORING AND EARLY WARNING TECHNOLOGY IN CHINA

Journal Article

Design, synthesis and HIV-RT inhibitory activity of novel thiazolidin-4-one derivatives

Hua CHEN, Zaihong GUO, Qingmei YIN, Xiaoxu DUAN, Yunjing GU, Xiaoliu LI

Journal Article

BIOINSECTICIDES AS FUTURE MAINSTREAM PEST CONTROL AGENTS: OPPORTUNITIES AND CHALLENGES

Journal Article

Pest management with biopesticides

James N. SEIBER, Joel COATS, Stephen O. DUKE, Aaron D. GROSS

Journal Article

SUSTAINABLE PLANT PEST MANAGEMENT THROUGH OPTIMIZATION AND MINIMIZATION

Plant Production and Protection Division (NSP), Food and Agriculture Organization of the United Nations (FAO), Viale delle Terme di Caracalla, 00153 Rome, Italy

Journal Article

Research on the business model innovation of wind power equipment manufacturing industry in China based on industrial chain

Hu Xuhua, ,,Shi Fangyan and Xu Junjie

Journal Article

Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD

Journal Article

A modular cable-driven humanoid arm with anti-parallelogram mechanisms and Bowden cables

Journal Article

Operation Mode of General Aviation Companies and Related Enterprises in China

Song Weiwei, Zhao Lijie, Xiang Song, Wang Yue, Li Zuoxue

Journal Article

Anti-biofouling strategies for implantable biosensors of continuous glucose monitoring systems

Journal Article

Lignin-derived dual-function red light carbon dots for hypochlorite detection and anti-counterfeiting

Journal Article

Modulatory effect on dyslipidemia and anti-atherosclerotic function of in newly diagnosed type 2 diabetes

SUN Mingxiao, WANG Yao, CHI Jiamin

Journal Article

Preparation of reverse osmosis membrane with high permselectivity and anti-biofouling properties for

Journal Article